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on the pituitary testicular axis in men: qualitative as well as quantitative changes in luteinizing hormone
j clin endocrinol metab 1985 ; 60 : 263-8
click here to see the library]
cette diminution progressive de la testostérone avec l’âge a été récemment confirmée en étudiant l’évolution d’une cohorte d’individus de manière longitudinale[14harman sm, metter ej, tobin jd, pearson j, blackman mr
longitudinal effects of aging on serum total and free testosterone levels. in healthy men
baltimore longitudinal study of aging
j clin endocrinol metab 2001 ; 86 : 724-31
click here to see the library]
le déclin débute en fait assez tôt dans la vie, dès la 4° décennie, avec une décroissance constante pendant toute la vie
ce déclin progressif n’aboutit à un déficit seulement pour une proportion des hommes
cette proportion augmente avec l’âge
ainsi le pourcentage de sujets, ayant une testostéronémie inférieure à la. normale (valeur normale établie chez des hommes jeunes) est de 7% entre 40 et 60 ans, 22% entre 60 et 80 ans et atteint 37% chez les hommes âgés de plus de 80 ans dans l’étude de l’équipe de vermeulen[56vermeulen a, kaufman jm, giagulli va
influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males
j clin endocrinol metab 1996 ; 81 : 1821-6
click here to see the library]
il a été noté la disparition des variations nycthémérales de la testostérone

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nintendo et microsoft confirment leur présence à l'e3 à la suite du playstation no show • eurogamer
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ultimate director masahiro sakurai appeared on stage yesterday at nintendo live 2018 to show off some of the singleplayer modes in nintendo’s latest crossover fighter
while classic mode will feature the usual 6-7 fights before a showdown with master hand, each character has their own “route” (which are also named), essentially a mini campaign of sorts against themed opponents
for example, jigglypuff’s route is called “64 all-stars”, and will heavily involve characters from the original smash bros
, as well as stages and music from that game as well
meanwhile, isabelle will need to face off against all 23 female fighters in her route
when you choose a difficulty for classic mode, you are brought to an elegant smash mural featuring the roster, and can then choose to dial the difficulty from 0
the smash mural features the cast of smash ultimate interacting with each other and fighting off shadowy creatures, but the left side (representing the lower difficulties) will be relatively peaceful compared to the right
[thanks, polonoid75 on reddit for the stitched image!]
after beating a stage, your difficulty will be raised, meaning even tougher battles to come
sakurai then showed off how different some routes can be – for ryu, the entire route will consist of 1v1 matches with items off and omega form stages on stamina mode, in order to make it more like the street fighter series
on the topic of street fighter, sakurai mentioned that both the cps-1 and cps-2 versions of all the fighter themes (plus the ‘pinch’ variations) are included in ultimate
the fight after ken was against zero suit samus, representing “a certain lady proficient with kicks and wearing blue”
after that comes a fight against a certain pro wrestler as well
it seems that in classic mode, music not usually found on that stage will play to fit with the route, as chun-li’s theme was shown playing on onett
it seems that the werewolf from castlevania, balder from bayonetta 2, and king bulbin from the legend of zelda: twilight princess will be world of light bosses
sakurai then went to show off spirits mode, stopping at the menu screen to show off the location of adventure mode as well
he explained that the spirits board where you can tackle spirit battles is randomized
choosing to go against tatanga, sakurai showed off the process of setting up spirits, and how you can easily skip the specifics by pressing y over and over for the recommended options
tatanga is represented by morton holding a super scope, and shooting items will constantly drop in, to represent the shmup-esque battle in the original game
meanwhile, fire man will have a mega man in red using nothing but down smash on norfair
some of the platforms will even be on fire to make it even harder
sakurai recommends equipping a fire platform-negating spirit, such as isuna from ever oasis, to deal with the heat
all battles against mega man bosses will also take place using stamina rules
sakurai showed off another battle, this time against nia from xenoblade chronicles 2
your fighter will need to face off against a mii brawler wearing nia’s mii costume, as well as incineroar
nia will also constantly heal hp, referencing her role in the original game
there are also a variety of support options to help you out if you require it
in the spirits board, there are support items that can immediately fill in gaps for spirits you’ve already beaten, as well as a shuffle item that swaps out all current ones with a new batch
during preparations, you can set up predetermined spirit setups that you can swap to easily
there are also some support items that make the spirit battle easier, like making the supporting enemy characters weaker
finally, when shooting spirits, you can use items that immediately breaks part of the shield, or use an item to slow down the roulette wheel
sakurai then showed off spirit raising, and how you can evolve certain spirits into stronger rarity versions
for example, by raising maria renard to lv
99, you can choose to evolve her into her symphony of the night version, which is higher in power and rarity but resets her level
meanwhile, naked snake can be evolved into big boss from metal gear solid v: ground zeroes after maxing him out
apart from these two, we can see shadow, mega man model x, and 5-volt as other characters who can get a stronger form
next, sakurai showed off sending home spirits and how to create new spirits using the cores left behind, with a cameo of raymond bryce from disaster:

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